The photosensitizer used in this study was benzoporphyrin derivative monoacid ring ‘a’ as supplied in a lipid formulated preparation under the generic name verteporfin.
Delayed photohemolysis of bovine red blood cells were investigated in this laboratory for sodium hypericin (HY-Na) and benzoporphyrin derivative monoacid ring A.
Overall drug loading was low, which indicated a greater tendency of the monoacid compound 2 to aggregate and settle out of the formulations.
They recently studied the biodistribution of tetra (m-hydroxyphenyl) chlorin and benzoporphyrin derivative monoacid ring A in the hamster model.
Visudyne-PDT (based on benzoporphyrin derivative monoacid ring A [BPD-MA]) was approved by the FDA in April 2000 for the treatment of a nonmalignant disease.