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词汇 nitrogen mustard
释义

Definition of nitrogen mustard in English:

nitrogen mustard

noun
Chemistry
  • Any of a group of organic compounds containing the group —N(CH₂CH₂Cl)₂. They are powerful cytotoxic alkylating agents and some are used in chemotherapy to treat cancer.

    〔化〕氮芥

    Example sentencesExamples
    • There was another name to become famous in cancer biology who worked on nitrogen mustard and on mustard gas, but whose name did not appear as a co-author on that famous paper.
    • Radiation from nuclear bombs and gaseous particles from nitrogen mustard and acridine orange have been used destructively in war.
    • Paradoxically, some nitrosocompounds were found to have antitumour activity and, like the nitrogen mustards described above, probably act by damaging the DNA in tumours in such a way that the cells cannot repair the damage and die.
    • Also during this time, the bone marrow suppressive effect of nitrogen mustard was discovered.
    • Chemicals such as mitomycin C and the nitrogen mustards generate inter-strand cross-links, while cisplatin (cis-diamine dichloroplatin) is associated with intra-strand cross-links.

Origin

1940s: mustard denoting a substance chemically similar to mustard gas.

Definition of nitrogen mustard in US English:

nitrogen mustard

noun
Chemistry
  • Any of a group of organic compounds containing the group —N(CH₂CH₂Cl)₂. They are powerful cytotoxic alkylating agents and some are used in chemotherapy to treat cancer.

    〔化〕氮芥

    Example sentencesExamples
    • There was another name to become famous in cancer biology who worked on nitrogen mustard and on mustard gas, but whose name did not appear as a co-author on that famous paper.
    • Paradoxically, some nitrosocompounds were found to have antitumour activity and, like the nitrogen mustards described above, probably act by damaging the DNA in tumours in such a way that the cells cannot repair the damage and die.
    • Also during this time, the bone marrow suppressive effect of nitrogen mustard was discovered.
    • Radiation from nuclear bombs and gaseous particles from nitrogen mustard and acridine orange have been used destructively in war.
    • Chemicals such as mitomycin C and the nitrogen mustards generate inter-strand cross-links, while cisplatin (cis-diamine dichloroplatin) is associated with intra-strand cross-links.

Origin

1940s: mustard denoting a substance chemically similar to mustard gas.

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