| 释义 |
Definition of alkylate in English: alkylateverb ˈalkɪleɪtˈalkəˌlāt [with object]usually as adjective alkylating" or "alkylatedChemistry Introduce an alkyl radical into (a compound) 〔化〕使烷基化 烷化剂。 Example sentencesExamples - Consistent with these functions, mei - 41 mutants are sensitive to hydroxyurea, an inhibitor of DNA replication, and DNA-damaging agents such as X-ray and alkylating agents.
- There has been some investigation into the natural alkylating agent 4-ipomeanol, but investigation was suspended after the first clinical trials.
- Several different types of drugs have been developed - alkylating agents, for example, inhibit cell division, whilst anti-metabolites interfere with enzyme systems and block vital processes.
- The mms4 mutant has previously been found to be sensitive to alkylating agents such as MMS, weakly sensitive to ultraviolet light, and resistant to X rays.
- Parp is activated by DNA strand breaks induced by alkylating agents.
- Acute leukemia frequently has been described as a late complication of chemotherapy with alkylating agents in patients treated for multiple myeloma.
- We found that it is also hypersensitive to various DNA-damaging agents, including UV irradiation and the DNA alkylating agent MMS.
- PARP is a nuclear enzyme activated by DNA strand breaks induced by alkylating agents or X-rays.
- The major categories are alkylating agents, antimetabolites, plant alkaloids, anti-tumor antibiotics, and steroid hormones.
- The chlorinated nitrosamines showed stronger mutagenicity than non-chlorinated nitrosamines, indicating that alkylating activity was strengthened by the presence of a chloro group.
- All four mutant lines displayed an increased sensitivity to the bifunctional alkylating agent mitomycin C.
- Chemical mutagens are classified as alkylating agents, cross-linking agents, and polycyclic aromatic hydrocarbons (PAHs).
- Methyl methanesulfonate and cyclophosphamide are alkylating agents that differ in their mode of action.
- Two men discovered that in the presence of Lewis acids (such as aluminum chloride or ferric chloride), alkyl halides will alkylate benzenes.
Derivativesnoun alkəˈleɪʃ(ə)n Chemistry The same sample was resolved into 7 distinct spots by acrylamide alkylation. Example sentencesExamples - Likewise the mustard nitrogen of chlorambucil should not be covalently joined to antibody, since it must be free to generate the toxic aziridinium ion responsible for DNA alkylation.
- These reactions occur via acylation or alkylation and are often rapid, forming stable primary amide or secondary amine bonds.
- Small alterations to bases, including oxidation and alkylation, are mainly repaired by the pathway known as base excision repair.
- Important synthetic methodology also exists for the alkylation of enolate ions.
Definition of alkylate in US English: alkylateverbˈalkəˌlāt [with object]usually as adjective alkylating" or "alkylatedChemistry Introduce an alkyl radical into (a compound) 〔化〕使烷基化 烷化剂。 Example sentencesExamples - Consistent with these functions, mei - 41 mutants are sensitive to hydroxyurea, an inhibitor of DNA replication, and DNA-damaging agents such as X-ray and alkylating agents.
- Acute leukemia frequently has been described as a late complication of chemotherapy with alkylating agents in patients treated for multiple myeloma.
- There has been some investigation into the natural alkylating agent 4-ipomeanol, but investigation was suspended after the first clinical trials.
- Parp is activated by DNA strand breaks induced by alkylating agents.
- The mms4 mutant has previously been found to be sensitive to alkylating agents such as MMS, weakly sensitive to ultraviolet light, and resistant to X rays.
- We found that it is also hypersensitive to various DNA-damaging agents, including UV irradiation and the DNA alkylating agent MMS.
- The chlorinated nitrosamines showed stronger mutagenicity than non-chlorinated nitrosamines, indicating that alkylating activity was strengthened by the presence of a chloro group.
- Several different types of drugs have been developed - alkylating agents, for example, inhibit cell division, whilst anti-metabolites interfere with enzyme systems and block vital processes.
- Methyl methanesulfonate and cyclophosphamide are alkylating agents that differ in their mode of action.
- Chemical mutagens are classified as alkylating agents, cross-linking agents, and polycyclic aromatic hydrocarbons (PAHs).
- The major categories are alkylating agents, antimetabolites, plant alkaloids, anti-tumor antibiotics, and steroid hormones.
- Two men discovered that in the presence of Lewis acids (such as aluminum chloride or ferric chloride), alkyl halides will alkylate benzenes.
- PARP is a nuclear enzyme activated by DNA strand breaks induced by alkylating agents or X-rays.
- All four mutant lines displayed an increased sensitivity to the bifunctional alkylating agent mitomycin C.
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