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词汇 antimetabolite
释义

Definition of antimetabolite in English:

antimetabolite

nounˌantɪmɪˈtabəlʌɪtˌantēmiˈtabəˌlīt
Physiology
  • A substance that interferes with the normal metabolic processes within cells, typically by combining with enzymes.

    〔生理〕抗代谢物,抗代谢药

    Example sentencesExamples
    • The class of anticancer drugs that has been developed to interfere with aspects of nucleotide metabolism is known as the antimetabolites.
    • With the latter therapy, once patients are weaned from steroids, the purine antimetabolite is continued for an indefinite period while the physician monitors white blood cell count and liver enzymes.
    • Clofarabine, a type of drug called a purine nucleoside antimetabolite, works by blocking the production and repair of DNA, the building blocks of genes.
    • Most forms of gout can be treated by administering the antimetabolite, allopurinol.
    • Methotrexate is an antimetabolite that, apart from its use in malignant disorders, is taken orally in low doses for the control of conditions such as rheumatoid arthritis and psoriasis.

Definition of antimetabolite in US English:

antimetabolite

nounˌantēmiˈtabəˌlīt
Physiology
  • A substance that interferes with the normal metabolic processes within cells, typically by combining with enzymes.

    〔生理〕抗代谢物,抗代谢药

    Example sentencesExamples
    • Clofarabine, a type of drug called a purine nucleoside antimetabolite, works by blocking the production and repair of DNA, the building blocks of genes.
    • Most forms of gout can be treated by administering the antimetabolite, allopurinol.
    • With the latter therapy, once patients are weaned from steroids, the purine antimetabolite is continued for an indefinite period while the physician monitors white blood cell count and liver enzymes.
    • The class of anticancer drugs that has been developed to interfere with aspects of nucleotide metabolism is known as the antimetabolites.
    • Methotrexate is an antimetabolite that, apart from its use in malignant disorders, is taken orally in low doses for the control of conditions such as rheumatoid arthritis and psoriasis.
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