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词汇 autophagy
释义

Definition of autophagy in English:

autophagy

noun ɔːˈtɒfədʒiôˈtäfəjē
mass nounBiology
  • 1Consumption of the body’s own tissue as a metabolic process occurring in starvation and certain diseases.

    the process of starvation-induced autophagy was recently the focus of extensive research
    Example sentencesExamples
    • While many scientists are trying to prevent the onset of a cancer defense mechanism known as autophagy, other researchers are leveraging it in a new therapy.
    • "We know that autophagy and neurodegeneration are connected, so pinpointing this protein is important to our understanding of the disease process."
    • In many infections, autophagy also helps digest pathogens and clear them away.
    • "Autophagy is a survival mechanism to ensure that the cell is able to obtain the necessary nutrients during times of starvation," explains Schmitz.
    • We aim to recruit a post-doctoral scientist to work on a research programme on autophagy and neurodegeneration using in vivo approaches in mice.
    1. 1.1 Destruction of damaged or redundant cellular components occurring in vacuoles within the cell.
      Example sentencesExamples
      • One of these proteins, which participate both in autophagy and cytoplasm-to-vacuole transport, is the Atg8 protein.
      • Moussa, who has long sought a way to force neurons to clean up their garbage, came up with the idea of using cancer drugs that push autophagy in tumors to help diseased brains.
      • It controls a number of metabolic processes important for cell growth, including nutrient import, transcription, and autophagy.
      • A primary pathway for the uptake of mitochondrial sequences by the nucleus may be provided by autophagy of mitochondria in cellular vacuoles (lysosomes).
      • Autophagy of entire chloroplasts during leaf senescence would cause a continuous decrease in the number of plastids per mesophyll cell.

Derivatives

  • autophagous

  • adjective ɔːˈtɒfəɡəs
    Biology
    • Guan and colleagues say it inhibits some non-autophagy enzymes, but activates autophagous ones.
      Example sentencesExamples
      • Plants are apparently autophagous all day long.
      • Note the fragments within the chloroplast and the autophagous vacuoles containing dark material.
      • He helped highlight the importance of autophagous processes in embryo development through mouse models.
      • These cells contained many lysosomal and autophagous bodies and damaged mitochondria.

Origin

Mid 19th century: from auto-1 + -phagy.

Definition of autophagy in US English:

autophagy

nounôˈtäfəjē
Biology
  • 1Consumption of the body’s own tissue as a metabolic process occurring in starvation and certain diseases.

    the process of starvation-induced autophagy was recently the focus of extensive research
    Example sentencesExamples
    • "We know that autophagy and neurodegeneration are connected, so pinpointing this protein is important to our understanding of the disease process."
    • "Autophagy is a survival mechanism to ensure that the cell is able to obtain the necessary nutrients during times of starvation," explains Schmitz.
    • We aim to recruit a post-doctoral scientist to work on a research programme on autophagy and neurodegeneration using in vivo approaches in mice.
    • While many scientists are trying to prevent the onset of a cancer defense mechanism known as autophagy, other researchers are leveraging it in a new therapy.
    • In many infections, autophagy also helps digest pathogens and clear them away.
    1. 1.1 Destruction of damaged or redundant cellular components occurring in vacuoles within the cell.
      Example sentencesExamples
      • Autophagy of entire chloroplasts during leaf senescence would cause a continuous decrease in the number of plastids per mesophyll cell.
      • A primary pathway for the uptake of mitochondrial sequences by the nucleus may be provided by autophagy of mitochondria in cellular vacuoles (lysosomes).
      • It controls a number of metabolic processes important for cell growth, including nutrient import, transcription, and autophagy.
      • Moussa, who has long sought a way to force neurons to clean up their garbage, came up with the idea of using cancer drugs that push autophagy in tumors to help diseased brains.
      • One of these proteins, which participate both in autophagy and cytoplasm-to-vacuole transport, is the Atg8 protein.

Origin

Mid 19th century: from auto- + -phagy.

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