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词汇 hepatotoxic
释义

Definition of hepatotoxic in English:

hepatotoxic

adjectiveˌhɛpətəʊˈtɒksɪkhɛˌpatəʊˈtɒksɪkˌhepədōˈtäksik
  • Damaging or destructive to liver cells.

    损害(或破坏)肝细胞的,肝细胞毒的

    Example sentencesExamples
    • Patients two to 21 years of age with acute lymphoblastic leukemia who are receiving hepatotoxic chemotherapy are being recruited for a second phase randomized pilot trial of silymarin.
    • When he discovered, in 1954, that dimethylnitrosamine was hepatotoxic he noticed that the poisoned livers contained enlarged cells similar to those seen in veno-occlusive disease.
    • Many herbal remedies are potentially hepatotoxic, and only milk thistle can be used safely in patients who have chronic liver disease.
    • Thus, clinicians may consider regimens with fewer potentially hepatotoxic agents in patients with advanced or unstable liver disease, and expert consultation is advisable in treating such patients.
    • However, in such patients hepatotoxic reactions to antituberculosis therapy may be more common and should therefore be anticipated.

Derivatives

  • hepatotoxicity

  • noun
    • The adverse effects of immediate-acting niacin preparations, including flushing, itching, gastrointestinal upset and hepatotoxicity, have limited their use.
      Example sentencesExamples
      • There were numerous reports of hepatotoxicity and aplastic anemia in adults, but there have been no reports of aplastic anemia in children younger than 13 years.
      • The pitfall was the almost immediate report of cases of fatal hepatotoxicity, a side effect not anticipated from results of the clinical trials.
      • Its side effects include hepatotoxicity, gastrointestinal symptoms, and dermatological reaction.
      • Other side effects include gastrointestinal upset, rash, hepatotoxicity, hypersensitivity and a flu-like syndrome.
  • hepatotoxin

  • nounˌhɛpətəʊˈtɒksɪnhɛˌpatəʊˈtɒksɪnˌhɛpədoʊˈtɑks(ə)n
    • They should also avoid or minimize alcohol use, because iron and alcohol are synergistic hepatotoxins.
      Example sentencesExamples
      • Vitamin A is a known hepatotoxin that is available over the counter.
      • Pyrrolizidine alkaloids present in comfrey tea and other plant materials are widely recognized as hepatotoxins.
      • When taken in larger doses, it becomes a potent hepatotoxin, generating fulminated hepatic and renal tubular necrosis which is lethal to humans and many species of animals.
      • Testing for hepatitis viruses A, B, and C should be performed and the patient questioned carefully regarding exposure to other possible hepatotoxins, especially alcohol.

Definition of hepatotoxic in US English:

hepatotoxic

adjectiveˌhepədōˈtäksik
  • Damaging or destructive to liver cells.

    损害(或破坏)肝细胞的,肝细胞毒的

    Example sentencesExamples
    • Thus, clinicians may consider regimens with fewer potentially hepatotoxic agents in patients with advanced or unstable liver disease, and expert consultation is advisable in treating such patients.
    • Patients two to 21 years of age with acute lymphoblastic leukemia who are receiving hepatotoxic chemotherapy are being recruited for a second phase randomized pilot trial of silymarin.
    • When he discovered, in 1954, that dimethylnitrosamine was hepatotoxic he noticed that the poisoned livers contained enlarged cells similar to those seen in veno-occlusive disease.
    • However, in such patients hepatotoxic reactions to antituberculosis therapy may be more common and should therefore be anticipated.
    • Many herbal remedies are potentially hepatotoxic, and only milk thistle can be used safely in patients who have chronic liver disease.
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