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词汇 acetylate
释义

Definition of acetylate in English:

acetylate

verb əˈsɛtɪleɪtəˈsedlˌāt
[with object]often as adjective acetylatedChemistry
  • Introduce an acetyl group into (a molecule or compound)

    〔化〕加乙酰基于(分子,化合物)

    the acetylated forms of chloramphenicol

    加乙酰基氯霉素。

    Example sentencesExamples
    • Serotonin in this gland is acetylated, then methylated, forming melatonin.
    • Histones (DNA packaging proteins) have lysine tails, which can be acetylated in a post-translational modification step.
    • In addition to histones, some HATs can acetylate non-histone proteins, suggesting multiple roles for these enzymes.
    • The proteins became acetylated instead, preventing glucose from attaching.
    • The N-terminal group was acetylated to reproduce the experimental conditions at which the protein was studied.

Derivatives

  • acetylation

  • noun
    Chemistry
    • Slowly, as researchers learned more about the structure of histones, it became evident that patterns of acetylation and methylation could be quite precise.
      Example sentencesExamples
      • From a dynamic point of view, histone-tail modifications, such as acetylation, phosphorylation, or methylation, are necessary to allow the activity of the chromatin remodeling complex.
      • The acetylation of salicylic acid increased the potency of morphine by making the compound more soluble in brain fat and facilitating transfer across the blood brain barrier.
      • This effect is consistent with the expected large reduction in electron density on the amino nitrogen upon acetylation thus making coordination with copper much less strong.
      • Important mechanisms for epigenetic alteration of gene expression include DNA methylation and histone acetylation.

Definition of acetylate in US English:

acetylate

verbəˈsedlˌāt
[with object]Chemistry
  • Introduce an acetyl group into (a molecule or compound)

    〔化〕加乙酰基于(分子,化合物)

    the acetylated forms of chloramphenicol

    加乙酰基氯霉素。

    Example sentencesExamples
    • In addition to histones, some HATs can acetylate non-histone proteins, suggesting multiple roles for these enzymes.
    • The proteins became acetylated instead, preventing glucose from attaching.
    • Histones (DNA packaging proteins) have lysine tails, which can be acetylated in a post-translational modification step.
    • The N-terminal group was acetylated to reproduce the experimental conditions at which the protein was studied.
    • Serotonin in this gland is acetylated, then methylated, forming melatonin.
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