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词汇 derepress
释义

Definition of derepress in English:

derepress

verbˌdiːrɪˈprɛsˌdēriˈpres
[with object]Biochemistry Genetics
  • Activate (enzymes, genes, etc.) from an inoperative or latent state.

    〔生化,遗传〕对(酶,基因)去阻遏(或去阻抑、去抑制)

    Example sentencesExamples
    • In addition, these mutations were able to derepress endogenous genes at HML.
    • Most of the genes are derepressed in the absence of a functional hns gene, indicating that H-NS mainly functions as a repressor.
    • Starvation for histidine derepresses the entire operon, the longest then known.
    • Blocking deacetylation by sodium butyrate or trichostatin A derepresses silent rRNA genes subject to nucleolar dominance.
    • About 3% of yeast genes are derepressed in tup1 mutants, as determined by microarray analysis.

Derivatives

  • derepression

  • noun
    Biochemistry Genetics
    • This suggests that glucose derepression is a permissive factor for clonal senescence.
      Example sentencesExamples
      • This model also predicts that deletion of the Set1 histone methyltransferase would lead to the derepression of subtelomeric genes.
      • The importance of the nucleosome in gene regulation is supported by the finding that mutations that alter intracellular levels of histones lead to transcriptional derepression of a variety of genes.
      • Indeed, guk1 and hpt1 mutants share several phenotypes (adenine derepression, purine excretion, and 8-azaguanine resistance).
      • However, whether derepression of the hTERT gene is the sole requirement for immortalization in all human cell types remained unresolved.

Definition of derepress in US English:

derepress

verbˌdēriˈpres
[with object]Genetics Biochemistry
  • Activate (enzymes, genes, etc.) from an inoperative or latent state.

    〔生化,遗传〕对(酶,基因)去阻遏(或去阻抑、去抑制)

    Example sentencesExamples
    • About 3% of yeast genes are derepressed in tup1 mutants, as determined by microarray analysis.
    • In addition, these mutations were able to derepress endogenous genes at HML.
    • Blocking deacetylation by sodium butyrate or trichostatin A derepresses silent rRNA genes subject to nucleolar dominance.
    • Starvation for histidine derepresses the entire operon, the longest then known.
    • Most of the genes are derepressed in the absence of a functional hns gene, indicating that H-NS mainly functions as a repressor.
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