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词汇 centromere
释义

Definition of centromere in English:

centromere

noun ˈsɛntrə(ʊ)mɪəˈsentrəˌmir
Biology
  • The region of a chromosome to which the microtubules of the spindle attach, via the kinetochore, during cell division.

    〔生〕着丝点,着丝粒

    Example sentencesExamples
    • The pertinent variable in this form of meiotic drive is the presence of differing numbers of centromeres on paired homologous chromosomes.
    • We observed an accumulation of cDNA loci near the centromere for seven chromosomes.
    • We conclude that chromosomes with damaged centromeres fail to correctly attach to the spindle, thus producing MN and monosomy.
    • In fact, we did not find any informative marker in the three chromosomal divisions around the centromere of this chromosome.
    • The presence of a kinetochore spot indicates the centromere region of each chromosome.

Derivatives

  • centromeric

  • adjective
    Biology
    • Strains were transformed with a control centromeric plasmid or a centromeric plasmid carrying the wild-type GUK1 gene.
      Example sentencesExamples
      • Signals from both subfamilies were mainly located in the centromeric regions of maize metaphase chromosomes.
      • In addition, binding of the yeast CBF3 kinetochore complex to centromeric DNA was severely compromised in this mutant.
      • In Drosophila, relocation of a euchromatic gene near centromeric or telomeric heterochromatin often leads to its mosaic silencing.
      • Each volume projection shows DNA in blue and a probe to the second chromosome centromeric heterochromatin in red.

Origin

Early 20th century (originally denoting a region within the oocyst of a malaria parasite): from Latin centrum (see centre) + Greek meros 'part'. The current sense dates from the 1930s.

Definition of centromere in US English:

centromere

nounˈsentrəˌmir
Biology
  • The region of a chromosome to which the microtubules of the spindle attach, via the kinetochore, during cell division.

    〔生〕着丝点,着丝粒

    Example sentencesExamples
    • We observed an accumulation of cDNA loci near the centromere for seven chromosomes.
    • The pertinent variable in this form of meiotic drive is the presence of differing numbers of centromeres on paired homologous chromosomes.
    • We conclude that chromosomes with damaged centromeres fail to correctly attach to the spindle, thus producing MN and monosomy.
    • In fact, we did not find any informative marker in the three chromosomal divisions around the centromere of this chromosome.
    • The presence of a kinetochore spot indicates the centromere region of each chromosome.

Origin

Early 20th century (originally denoting a region within the oocyst of a malaria parasite): from Latin centrum (see center) + Greek meros ‘part’. The current sense dates from the 1930s.

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